Lidocaine+Hydrocortisone
Lidocaine: Lidocaine is amide-type local anesthesia. It stabilizes the neuronal membrane and inhibits Na ion movements, which are necessary for the conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Dosage & Administration:
Apply twice daily around the anal opening in a thin layer using an applicator.
Interaction:
This cream should be used with caution together with dental injection anesthesia, other local anesthetics, or agents structurally related to local anesthetics of amide-type eg, antiarrhythmic drugs (eg, mexiletine), as the toxic effects of these drugs are addictive.
Patients treated with class III antiarrhythmic drugs (eg, amiodarone) should be closely observed and ECG monitoring should be considered, as the cardiac effects of lidocaine and class III antiarrhythmic drugs can be addictive.
Drugs that inhibit the metabolism of lidocaine (eg, cimetidine or ?-blockers) may cause potentially toxic plasma concentrations when the lidocaine is given in repeated high doses over a long time period. Such interactions are of no clinical importance following short-term treatment with lidocaine at recommended doses.
Contraindications:
Patients with a history of hypersensitivity to any of its ingredients.
Side Effects:
Side effects like Rectal bleeding, Swelling of the skin, Adrenal suppression, Anaphylaxis, Angioedema, Cushing syndrome, Hirsutism, Acne, Cutaneous and subcutaneous atrophy, dry scaly skin, Urticaria.
Pregnancy & Lactation:
Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Lactation: Unknown if distributed in breast milk; exercise caution
Precautions & Warnings:
If extensive areas are treated, the possibility of systemic absorption exists. Systemic absorption of topical steroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glycosuria in some patients. If irritation or sensitivity occurs or infection appears, discontinue use and institute appropriate therapy.
If you miss a dose, use it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Therapeutic Class: Gastro-Intestinal Disorders / Drugs used in the Ano-rectal region
Indications:
Hydrocortisone plus Lidocaine cream is used for the anti-inflammatory and anesthetic relief of itching, pain, soreness, and discomfort due to hemorrhoids, anal fissures, pruritus ani, and similar conditions of the anal area.
Description:
Hydrocortisone: Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and the reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Indications:
Hydrocortisone plus Lidocaine cream is used for the anti-inflammatory and anesthetic relief of itching, pain, soreness, and discomfort due to hemorrhoids, anal fissures, pruritus ani, and similar conditions of the anal area.
Description:
Hydrocortisone: Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and the reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Lidocaine: Lidocaine is amide-type local anesthesia. It stabilizes the neuronal membrane and inhibits Na ion movements, which are necessary for the conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Dosage & Administration:
Apply twice daily around the anal opening in a thin layer using an applicator.
Interaction:
This cream should be used with caution together with dental injection anesthesia, other local anesthetics, or agents structurally related to local anesthetics of amide-type eg, antiarrhythmic drugs (eg, mexiletine), as the toxic effects of these drugs are addictive.
Patients treated with class III antiarrhythmic drugs (eg, amiodarone) should be closely observed and ECG monitoring should be considered, as the cardiac effects of lidocaine and class III antiarrhythmic drugs can be addictive.
Drugs that inhibit the metabolism of lidocaine (eg, cimetidine or ?-blockers) may cause potentially toxic plasma concentrations when the lidocaine is given in repeated high doses over a long time period. Such interactions are of no clinical importance following short-term treatment with lidocaine at recommended doses.
Contraindications:
Patients with a history of hypersensitivity to any of its ingredients.
Side Effects:
Side effects like Rectal bleeding, Swelling of the skin, Adrenal suppression, Anaphylaxis, Angioedema, Cushing syndrome, Hirsutism, Acne, Cutaneous and subcutaneous atrophy, dry scaly skin, Urticaria.
Pregnancy & Lactation:
Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Lactation: Unknown if distributed in breast milk; exercise caution
Precautions & Warnings:
If extensive areas are treated, the possibility of systemic absorption exists. Systemic absorption of topical steroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glycosuria in some patients. If irritation or sensitivity occurs or infection appears, discontinue use and institute appropriate therapy.
Overdose:
This cream may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing. This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in that case.If you miss a dose, use it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Storage:
Store at controlled room temperature of 15°C to 30°C, protect from freezing. Keep out of the reach of children.
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