Miconazole Nitrate + Hydrocortisone
Therapeutic Class: Hydrocortisone & Combined preparations
Indications:
For the topical treatment of inflamed dermatoses where infection by susceptible organisms and inflammation coexist e.g. intertrigo and infected eczema. For moist or dry eczema or dermatitis including atopic eczema, primary irritant or contact allergic eczema, or seborrheic eczema including that associated with acne. Also for intertriginous eczema including inflammatory interigo, perianal and genital dermatitis. Organisms that are susceptible to miconazole are dermatophytes and pathogenic yeasts (e.g. Candida spp.): also many Gram-positive bacteria including many strains of Streptococcus and Staphylococcus.
Description:
Miconazole is a substituted imidazole, is one of the families of azoles useful in treating the superficial candidiasis and of the skin infections dermatophytosis and pityriasis Versicolor, acanthameaba, seborrhoic dermatitis. Also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii, and some gram-positive bacteria including Staphylococci and Streptococci. Hydrocortisone is a naturally occurring glucocorticoid that's now prepared synthetically. Its important function is in skin injury such as inflammation. Also, it has antipruritic, antimycotic and vasoconstrictive activity.
Miconazole is an imidazole antifungal agent that interferes with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi. This causes the killing of fungi, when applied to the skin, Hydrocortisone is absorbed into the skin cells. It prevents the release of certain chemicals, which are responsible for inflammation. Thus hydrocortisone reduces inflammation.
Dosage & Administration:
Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream fully vanished on the skin. Treatment should be continued at least one week after the disappearance of all signs and symptoms. The same dosage applies to both adults and children. Take care or consult with a physician in case of use in children and elderly people for long-term use.
Interaction:
Amphotericin antagonizes the effect of miconazole.
Contraindications:
Hypersensitivity to any of the ingredients. Tubercular or viral infections of the skin or those caused by gram-negative bacteria.
Side Effects:
Rarely local sensitivity may occur. Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
Pregnancy & Lactation:
Administration of corticosteroids to pregnant animals at high doses can cause abnormalities of fetal development. Topical steroids should not be extensively used in pregnancy.
Precautions & Warnings:
It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Application to the extensive surface areas of the face should be avoided. In infants, long-term continuous topical corticosteroid therapy should be avoided. Adrenal suppression may occur even without occlusion.
Storage:
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
Indications:
For the topical treatment of inflamed dermatoses where infection by susceptible organisms and inflammation coexist e.g. intertrigo and infected eczema. For moist or dry eczema or dermatitis including atopic eczema, primary irritant or contact allergic eczema, or seborrheic eczema including that associated with acne. Also for intertriginous eczema including inflammatory interigo, perianal and genital dermatitis. Organisms that are susceptible to miconazole are dermatophytes and pathogenic yeasts (e.g. Candida spp.): also many Gram-positive bacteria including many strains of Streptococcus and Staphylococcus.
Description:
Miconazole is a substituted imidazole, is one of the families of azoles useful in treating the superficial candidiasis and of the skin infections dermatophytosis and pityriasis Versicolor, acanthameaba, seborrhoic dermatitis. Also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii, and some gram-positive bacteria including Staphylococci and Streptococci. Hydrocortisone is a naturally occurring glucocorticoid that's now prepared synthetically. Its important function is in skin injury such as inflammation. Also, it has antipruritic, antimycotic and vasoconstrictive activity.
Miconazole is an imidazole antifungal agent that interferes with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi. This causes the killing of fungi, when applied to the skin, Hydrocortisone is absorbed into the skin cells. It prevents the release of certain chemicals, which are responsible for inflammation. Thus hydrocortisone reduces inflammation.
Dosage & Administration:
Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream fully vanished on the skin. Treatment should be continued at least one week after the disappearance of all signs and symptoms. The same dosage applies to both adults and children. Take care or consult with a physician in case of use in children and elderly people for long-term use.
Interaction:
Amphotericin antagonizes the effect of miconazole.
Contraindications:
Hypersensitivity to any of the ingredients. Tubercular or viral infections of the skin or those caused by gram-negative bacteria.
Side Effects:
Rarely local sensitivity may occur. Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
Pregnancy & Lactation:
Administration of corticosteroids to pregnant animals at high doses can cause abnormalities of fetal development. Topical steroids should not be extensively used in pregnancy.
Precautions & Warnings:
It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Application to the extensive surface areas of the face should be avoided. In infants, long-term continuous topical corticosteroid therapy should be avoided. Adrenal suppression may occur even without occlusion.
Storage:
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
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