Menthol + Camphor + Methyl Salicylate + Oleoresin Capsicum
Therapeutic Class: Herbal and Nutraceuticals, Topical Analgesics, Topical anti-inflammatory preparations
Indications:
Muscle pain Sprains, strains, and sports injuries, headache bruising, fibrositis, neuralgia, pain due to herpes zoster, osteoarthritis
Indications:
Muscle pain Sprains, strains, and sports injuries, headache bruising, fibrositis, neuralgia, pain due to herpes zoster, osteoarthritis
Presentation:
Each gm muscle rub contains-
The fresh or dried fruits of different Capsicum species are used medicinally. Capsicum oleoresin is prepared by extracting the crushed capsicum with volatile solvents by percolation method. Preparation made from the oleoresin in cayenne and oleoresin's isolated constituent 'Capsaicin' is used as a topical analgesic in OTC (over-the-counter) market. The herb is indigenous to Mexico and Central America. Methyl salicylate, menthol, and camphor are originally derived from plants. Methyl salicylate is derived from the oil of wintergreen, menthol is derived from mint, and camphor is derived from a number of plants including Peppermint, Eucalyptus, and Cedar.
Pharmacology:
Capsicum species are known to be very strong local stimulants in the circulatory system. Its reduction of thromboxane B2 formation and erythrocyte hemolysis suggests a membrane-stabilizing property that interferes with the activation of phospholipase A2. Capsicum activates nociceptive fibers, which induce the release of excitatory neurotransmitters, bind to specific vanilloid (capsaicin) receptors and its effects are reversible. Capsicum induces a selective analgesic effect by depleting the substance P, a neuropeptide of 11 amino acids that mediates the transmission and modulation of pain impulses from the peripheral nerves to the spinal column. Capsicum initially stimulates substance P release from peripheral sensory C type nerve fibers, then prevents its re-uptake and also blocks its transport within the neuron, which causes its eventual depletion resulting in analgesia.
Methyl salicylic acid is similar to that of Aspirin that shows anesthetic properties by blocking the voltage-operated sodium channels in pain-receptor neurons.
Menthol molecule binds and stimulates the TRPM-8 receptor protein that produces a sensation of cold (pain in extreme cases) when stimulated.
Camphor has been approved by FDA for topical use as a pain reliever and anesthetic. It acts as a counter-irritant and numbs the nerve endings that inhibit the transmission of pain sensation.
Dosage & Administration:
In rare cases, a hypersensitivity reaction may occur. Inhalation of medicine may cause bronchoconstriction.
Contraindications:
Capsicum preparations are contraindicated for application on injured skin, allergies to aspirin, allergic inflammation of the skin, eczema, itchy rash, and near the eyes.
Pregnancy & Lactation:
There is no information available about the restriction of this medicine during pregnancy and lactation. May be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks of the fetus.
Precautions & Warnings:
Avoid use on broken or inflamed skin, eyes, and mucous membranes. Rinse with cold water if accidental contact occurs. Do not cover immediately after application. Wash your hands thoroughly after application. If itching or irritation occurs discontinue it.
Storage:
Store at a cool, dry place and away from direct sunlight. Keep the medicine out of the reach of children.
Each gm muscle rub contains-
- L-Menthol 25.40 mg
- D-camphor 14.30 mg
- Methyl Salicylate 4.20 mg
- Oleoresin Capsicum 0.05 mg
The fresh or dried fruits of different Capsicum species are used medicinally. Capsicum oleoresin is prepared by extracting the crushed capsicum with volatile solvents by percolation method. Preparation made from the oleoresin in cayenne and oleoresin's isolated constituent 'Capsaicin' is used as a topical analgesic in OTC (over-the-counter) market. The herb is indigenous to Mexico and Central America. Methyl salicylate, menthol, and camphor are originally derived from plants. Methyl salicylate is derived from the oil of wintergreen, menthol is derived from mint, and camphor is derived from a number of plants including Peppermint, Eucalyptus, and Cedar.
Pharmacology:
Capsicum species are known to be very strong local stimulants in the circulatory system. Its reduction of thromboxane B2 formation and erythrocyte hemolysis suggests a membrane-stabilizing property that interferes with the activation of phospholipase A2. Capsicum activates nociceptive fibers, which induce the release of excitatory neurotransmitters, bind to specific vanilloid (capsaicin) receptors and its effects are reversible. Capsicum induces a selective analgesic effect by depleting the substance P, a neuropeptide of 11 amino acids that mediates the transmission and modulation of pain impulses from the peripheral nerves to the spinal column. Capsicum initially stimulates substance P release from peripheral sensory C type nerve fibers, then prevents its re-uptake and also blocks its transport within the neuron, which causes its eventual depletion resulting in analgesia.
Methyl salicylic acid is similar to that of Aspirin that shows anesthetic properties by blocking the voltage-operated sodium channels in pain-receptor neurons.
Menthol molecule binds and stimulates the TRPM-8 receptor protein that produces a sensation of cold (pain in extreme cases) when stimulated.
Camphor has been approved by FDA for topical use as a pain reliever and anesthetic. It acts as a counter-irritant and numbs the nerve endings that inhibit the transmission of pain sensation.
Dosage & Administration:
- Adult: Clean the affected area. Apply a small amount of this cream to the surface area of the tip of a finger 3 to 4 times daily or as directed by the physician.
- Children under 6 years of age: Not to be used.
In rare cases, a hypersensitivity reaction may occur. Inhalation of medicine may cause bronchoconstriction.
Contraindications:
Capsicum preparations are contraindicated for application on injured skin, allergies to aspirin, allergic inflammation of the skin, eczema, itchy rash, and near the eyes.
Pregnancy & Lactation:
There is no information available about the restriction of this medicine during pregnancy and lactation. May be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks of the fetus.
Precautions & Warnings:
Avoid use on broken or inflamed skin, eyes, and mucous membranes. Rinse with cold water if accidental contact occurs. Do not cover immediately after application. Wash your hands thoroughly after application. If itching or irritation occurs discontinue it.
Storage:
Store at a cool, dry place and away from direct sunlight. Keep the medicine out of the reach of children.
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