Travoprost: Uses,Dosage,Side Effects

Generic Name
Travoprost
Therapeutic Class:
Ophthalmic

Indications:
Travoprost Eye Drops are indicated for the reduction of intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension. 

Presentation:
Travoprost sterile eye drops: Each ml contains 40 microgram of Travoprost USP.

Description:
Travoprost is a clear, colorless to a slightly yellow oil. Travoprost ophthalmic solution is supplied as a sterile, buffered aqueous solution of travoprost.

Dosage & Administration:
Use in adults
One drop in the affected eye once daily in the evening. The dosage of Travast should not exceed once daily since it has been shown that more frequent administration may decrease the normal intraocular pressure.

Paediatric patients
The efficacy and safety of travoprost eye drops in patients below the age of 18 years have not been established.

Side Effects:
The most common ocular adverse effect is ocular hyperemia. Ocular adverse events reported at an incidence of 5-10% included decreased visual acuity, eye discomfort, foreign body sensation, pain, and pruritus. Ocular adverse events reported at an incidence of 1-4% included abnormal vision, blepharitis, blurred vision, cataract, conjunctivitis, dry eye, flare, iris discoloration, keratitis, lid margin crusting, photophobia, subconjunctival hemorrhage, and tearing.

Precautions:
Travoprost eye drops should be used with caution in patients with active intraocular inflammation & macular edema. In the case of patients with mild to severe hepatic impairment and renal impairment (creatinine clearance as low as 14 ml/min), no dosage adjustment is necessary. Travoprost should not be administered while wearing contact lenses. Lenses may be reinserted 15 minutes following administration of Travast eye drop.

Use in Pregnancy & Lactation:
Pregnancy category C. It is unknown whether travoprost from eye drops is excreted in human breast milk. Animal studies have shown the excretion of travoprost and metabolites in breast milk. The use of Travast by breastfeeding mothers is not recommended.

Interaction:
No specific interaction was observed with Travast eye drops.

Overdose:
No cases of overdose have been reported.

Storage:
Store below 25º C in a dry place. Keep out of reach of children. The solution can be used up to 30 days after the first opening. 
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