Generic Name
TobramycinTherapeutic Class: Ophthalmic
Indications:
Intobac eye drops is a topical antibiotic indicated in the treatment of external bacterial infections of the eye and its adnexa caused by susceptible organisms:
Gram-positive microorganisms:
Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumonia,
Streptococcus sp. of group A beta-hemolytic and some nonhemolytic species.
Gram-negative microorganisms:
Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella sp., Proteus mirabillis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, some strains of Neisseria, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella sp.
Presentation:
Tobramycin 0.3% eye drops: Each ml contains Tobramycin USP 3 mg.
Description:
Intobac is a broad-spectrum, aminoglycoside antibiotic of bacteriocidal type of action.
It works by inhibition of bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome.
Intobac eye drops is a topical antibiotic indicated in the treatment of external bacterial infections of the eye and its adnexa caused by susceptible organisms:
Gram-positive microorganisms:
Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumonia,
Streptococcus sp. of group A beta-hemolytic and some nonhemolytic species.
Gram-negative microorganisms:
Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella sp., Proteus mirabillis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, some strains of Neisseria, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella sp.
Presentation:
Tobramycin 0.3% eye drops: Each ml contains Tobramycin USP 3 mg.
Description:
Intobac is a broad-spectrum, aminoglycoside antibiotic of bacteriocidal type of action.
It works by inhibition of bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome.
Dosage & Administration:
Adults: If the infection is mild to moderate, 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, 2 drops into the eye(s) every hour until there is an improvement, following which treatment should be reduced prior to discontinuation.
Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 months have not been established.
Side Effects:
Localized ocular toxicity and hypersensitivity, including lid itching and swelling, conjunctival erythema, and lacrimation
Precautions:
Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to tobramycin occurs, discontinue use. Prolonged use may lead to skin sensitization or result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs appropriate therapy should be initiated
Use in Pregnancy & Lactation:
Pregnancy Category B. Reproduction studies in three types of animals at doses up to thirty-three times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Overdose:
Signs and symptoms of overdose may be similar to side effects as described above
Storage:
Adults: If the infection is mild to moderate, 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, 2 drops into the eye(s) every hour until there is an improvement, following which treatment should be reduced prior to discontinuation.
Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 months have not been established.
Side Effects:
Localized ocular toxicity and hypersensitivity, including lid itching and swelling, conjunctival erythema, and lacrimation
Precautions:
Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to tobramycin occurs, discontinue use. Prolonged use may lead to skin sensitization or result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs appropriate therapy should be initiated
Use in Pregnancy & Lactation:
Pregnancy Category B. Reproduction studies in three types of animals at doses up to thirty-three times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Overdose:
Signs and symptoms of overdose may be similar to side effects as described above
Storage:
- Protect from light.
- Store below 25 °C.
- Keep out of reach of children.
- Do not use more than 4 weeks after opening
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