Generic Name
SecnidazoleTherapeutic Class: Anti Protozoal (Amoebicides, Anti-diarrhoeal Antiprotozoal)
Indications:
Each film-coated tablet contains Secnidazole INN 1 gm.
Description:
Secnidazole is the first nitroimidazole to offer a 3-day antiprotozoal activity from one single dose. With its prolonged half-life, Secnidazole offers an effective treatment and thus ensures improved patient compliance because of the short duration of treatment with excellent therapeutic efficacy.
Secnidazole exhibits activity against anaerobic protozoa Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis.
Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole.
The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours).
Dosage & Administration:
Secnidazole tablet
- Intestinal Amoebiasis
- Hepatic Amoebiasis
- Urethritis and Vaginitis due to Trichomonas vaginalis
- Giardiasis
Each film-coated tablet contains Secnidazole INN 1 gm.
Description:
Secnidazole is the first nitroimidazole to offer a 3-day antiprotozoal activity from one single dose. With its prolonged half-life, Secnidazole offers an effective treatment and thus ensures improved patient compliance because of the short duration of treatment with excellent therapeutic efficacy.
Secnidazole exhibits activity against anaerobic protozoa Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis.
Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole.
The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours).
Dosage & Administration:
Secnidazole tablet
should be administered orally. The dosage schedule of Secnidazole tablet is mentioned below:
Amoebiasis:
-Acute intestinal amoebiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 30 mg/kg single dose, taken preferably just before a meal.
-Asymptomatic amoebiasis (minute & cystic form):
Adults: 2 gm once daily (2x1 gm tablet) for only 3 days, taken preferably just before a meal.
Children: 30 mg/kg once daily for only 3 days, taken preferably just before a meal.
Hepatic amoebiasis:
Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days.
Children: 30 mg/kg/day, in a single or divided dose, just before mal for 5 days.
N.B.: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.
Giardiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 35-50 mg/kg single dose, taken preferably just before a meal.
Trichomoniasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 30 mg/kg single dose, taken preferably just before a meal.
The partner should also receive the same treatment concomitantly.
Secnidazole Suspension:
-Acute intestinal amoebiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 30 mg/kg single dose, taken preferably just before a meal.
-Asymptomatic amoebiasis (minute & cystic form):
Adults: 2 gm once daily (2x1 gm tablet) for only 3 days, taken preferably just before a meal.
Children: 30 mg/kg once daily for only 3 days, taken preferably just before a meal.
Hepatic amoebiasis:
Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days.
Children: 30 mg/kg/day, in a single or divided dose, just before mal for 5 days.
N.B.: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.
Giardiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 35-50 mg/kg single dose, taken preferably just before a meal.
Trichomoniasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before a meal.
Children: 30 mg/kg single dose, taken preferably just before a meal.
The partner should also receive the same treatment concomitantly.
Secnidazole Suspension:
Suspension should be administered orally. The dosage schedule of Secnidazole suspension is mentioned below:
Children of 10 to 15 kg body weight: 1 bottle of Secnidazole 500 mg suspension.
Children of 16 to 25 kg body weight: 1½ bottle of Secnidazole 500 mg suspension.
Children of 26 kg or more body weight: 2 bottles of Secnidazole 500 mg suspension.
Side Effects:
The clinical studies have shown that Secnidazole is characterized by very good tolerance and no serious adverse reactions have been reported to date.
The following side-effects may be observed with Secnidazole as with all nitroimidazole derivatives & are rarely serious
Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, and stomatitis.
Occasional side-effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and peripheral neuropathy.
With Secnidazole, gastrointestinal disorders e.g, nausea, vomiting, epigastric pain, etc. have been reported in very rare cases.
Precautions:
Secnidazole is contraindicated for those patients who are hypersensitive to imidazole derivatives. Patients should be advised not to take alcohol during treatment with Secnidazole (because of the possibility of the Antabuse effect). Administration of Secnidazole should be avoided in patients with a history of blood dyscrasia.
Use in Pregnancy & Lactation:
Secnidazole may be prescribed in pregnancy after the first trimester. As with other similar drugs, Secnidazole should not be administered during the first trimester of pregnancy or during lactation because Secnidazole is found in the placenta and breast milk.
Storage:
Store in a cool dry place, protected from heat.
Children of 10 to 15 kg body weight: 1 bottle of Secnidazole 500 mg suspension.
Children of 16 to 25 kg body weight: 1½ bottle of Secnidazole 500 mg suspension.
Children of 26 kg or more body weight: 2 bottles of Secnidazole 500 mg suspension.
Side Effects:
The clinical studies have shown that Secnidazole is characterized by very good tolerance and no serious adverse reactions have been reported to date.
The following side-effects may be observed with Secnidazole as with all nitroimidazole derivatives & are rarely serious
Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, and stomatitis.
Occasional side-effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and peripheral neuropathy.
With Secnidazole, gastrointestinal disorders e.g, nausea, vomiting, epigastric pain, etc. have been reported in very rare cases.
Precautions:
Secnidazole is contraindicated for those patients who are hypersensitive to imidazole derivatives. Patients should be advised not to take alcohol during treatment with Secnidazole (because of the possibility of the Antabuse effect). Administration of Secnidazole should be avoided in patients with a history of blood dyscrasia.
Use in Pregnancy & Lactation:
Secnidazole may be prescribed in pregnancy after the first trimester. As with other similar drugs, Secnidazole should not be administered during the first trimester of pregnancy or during lactation because Secnidazole is found in the placenta and breast milk.
Storage:
Store in a cool dry place, protected from heat.
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