Generic Name
Procyclidine HydrochlorideTherapeutic Class: Drugs of Nervous System (Antiparkinson drugs)
Indications:
All forms of Parkinson's disease -
Procyclidine 5: Each tablet contains Procyclidine Hydrochloride BP 5 mg.
Procyclidine Injection: Each 2 ml ampoule contains Procyclidine Hydrochloride BP 10 mg.
Description:
Procyclidine is an antimuscarinic tertiary amine, which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits a direct antispasmodic effect on smooth muscle.
Dosage & Administration:
Oral-
Symptomatic treatment of Parkinsonism and drug-induced extrapyramidal syndrome:
Adult: Initially 2.5 mg t.i.d increased gradually by 2.5-5 mg every 2-3 days if required. The maintenance dose is 20-30 mg/day in 3 divided doses.
Elderly: The preferably lower range is required.
Children: Safety and efficacy have not been established in the pediatric age group; therefore, the use of Cyclid in this age group requires that the potential benefits be weighed against the possible risk to the child.
Parenteral-
Symptomatic treatment of Parkinsonism and drug-induced extrapyramidal syndrome:
Adult: Emergency cases 5-10 mg IM/IV. IM may be repeated if necessary after 20 min up to 20 mg/day
Side Effects:
Excitability, dizziness, hallucinations, dry mouth, blurred vision, constipation, urinary retention, agitation, restlessness, confusion and convulsions, sedation rather than stimulation, and gingivitis may be observed.
Precautions:
Precaution should be taken in case of hepatic & renal impairment, children, elderly, pregnancy, and lactation condition. Patients with mental disorders occasionally experience precipitation of a psychotic episode when Procyclidine is administered for the treatment of the extrapyramidal side-effects of neuroleptic. Procyclidine should not be withdrawn abruptly as rebound Parkinsonism symptoms may occur.
Use in Pregnancy & Lactation:
No data is advisable on the safe use of this drug in pregnancy and lactation.
Interaction:
Phenothiazines, anticonvulsants, levodopa, ketoconazole, monoamine oxidase inhibitors, adsorbent, anti-diarrhoeal, alcohol, anticholinergic drugs may interact with the Procyclidine.
Storage:
Protect from light and moisture, store below 25°C. Keep out of the reach of children.
All forms of Parkinson's disease -
- Idiopathic Parkinsonism
- Post-encephalitic Parkinsonism
- Arteriosclerotic Parkinsonism
- Extrapyramidal symptoms -
- Pseudo-parkinsonism
- Acute dystonic reactions
- Akathisia.
Procyclidine 5: Each tablet contains Procyclidine Hydrochloride BP 5 mg.
Procyclidine Injection: Each 2 ml ampoule contains Procyclidine Hydrochloride BP 10 mg.
Description:
Procyclidine is an antimuscarinic tertiary amine, which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits a direct antispasmodic effect on smooth muscle.
Dosage & Administration:
Oral-
Symptomatic treatment of Parkinsonism and drug-induced extrapyramidal syndrome:
Adult: Initially 2.5 mg t.i.d increased gradually by 2.5-5 mg every 2-3 days if required. The maintenance dose is 20-30 mg/day in 3 divided doses.
Elderly: The preferably lower range is required.
Children: Safety and efficacy have not been established in the pediatric age group; therefore, the use of Cyclid in this age group requires that the potential benefits be weighed against the possible risk to the child.
Parenteral-
Symptomatic treatment of Parkinsonism and drug-induced extrapyramidal syndrome:
Adult: Emergency cases 5-10 mg IM/IV. IM may be repeated if necessary after 20 min up to 20 mg/day
Side Effects:
Excitability, dizziness, hallucinations, dry mouth, blurred vision, constipation, urinary retention, agitation, restlessness, confusion and convulsions, sedation rather than stimulation, and gingivitis may be observed.
Precautions:
Precaution should be taken in case of hepatic & renal impairment, children, elderly, pregnancy, and lactation condition. Patients with mental disorders occasionally experience precipitation of a psychotic episode when Procyclidine is administered for the treatment of the extrapyramidal side-effects of neuroleptic. Procyclidine should not be withdrawn abruptly as rebound Parkinsonism symptoms may occur.
Use in Pregnancy & Lactation:
No data is advisable on the safe use of this drug in pregnancy and lactation.
Interaction:
Phenothiazines, anticonvulsants, levodopa, ketoconazole, monoamine oxidase inhibitors, adsorbent, anti-diarrhoeal, alcohol, anticholinergic drugs may interact with the Procyclidine.
Protect from light and moisture, store below 25°C. Keep out of the reach of children.
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