Vitamin E: Uses,Dosage,Side Effects

Generic Name
Vitamin E
Therapeutic Class: Vitamins and Minerals

Indications:
As a dietary supplement for prophylactic use:
To meet raised requirements of vitamin E in pregnancy and lactation, high dietary intake of polyunsaturated fatty acids, etc.

For prevention of vitamin E deficiency due to malabsorption syndrome caused by pancreatic, hepatobiliary, and gastrointestinal disorders.

Therapeutic use:
In cardiovascular disease, hemolytic anemia due to vitamin E deficiency, skin conditions, nocturnal leg cramps, sexual dysfunction, premenstrual syndrome, and fibrocystic disease of the breast.

Presentation
Vitamin E 200: Each capsule contains Alpha Tocopheryl Acetate BP 200 mg.
Vitamin E 400: Each capsule contains Alpha Tocopheryl Acetate BP 400 mg.

Description:
Vitamin E, a fat-soluble vitamin, is considered an essential nutritional element. As an antioxidant, it protects polyunsaturated fatty acids in cell membranes and other cellular structures from free radicals and protects red blood cells against haemolysis. It may also act as a cofactor in some enzyme systems. Administration of vitamin E completely eliminates the signs of vitamin E deficiency. Vitamin E is absorbed from the gastrointestinal tract and requires the presence of bile salts, dietary fat, and normal pancreatic function for efficient absorption. It is metabolized in the liver and excreted primarily in bile. Small amounts are excreted in the urine.

Dosage & Administration:
The daily intake of Inovit E (Vitamin E) in the range of 200 - 600 mg is considered safe. The recommended dose is one capsule once daily with or after meals or as prescribed by the physician.

Side Effects:
Vitamin E is usually well tolerated. Large doses (more than 400 mg/day) for a prolonged period have been associated with a variety of less serious side effects including fatigue, weakness, headache, nausea, blurred vision, flatulence, or diarrhea.

Precautions:
It may increase the risk of thrombosis in some patients, such as those taking estrogens.

Use in Pregnancy & Lactation:
Pregnancy: Vitamin E may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established.
Nursing Mother: Vitamin E is distributed in human breast milk; however, problems have not been documented with the normally recommended dose.

Drug Interaction:
A high dose of vitamin E can impair intestinal absorption of vitamin A & K and may increase the effects of oral anticoagulants.

Over Dose:
Large doses of vitamin E (more than 1 gm/day) have been reported to increase bleeding tendency in vitamin K deficient patients such as those taking oral anticoagulants.

Storage:
Keep in a dry place far away from light and warmth. exclude the reach of Children's.
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