Vitamin-B complex & Vitamin C
Therapeutic Class: Vitamins and Minerals
Vitamin-B complex & Vitamin C IV is indicated as a supplement for intravenous nutrition in order to meet the daily requirements of the water-soluble vitamins in infants, adults, and children.
Presentation:
Each 10 ml vial contains: Vitamin B1 BP 2.5 mg, Vitamin B2 BP 3.6 mg, Nicotinamide BP 40 mg, Vitamin B6 BP 4 mg, Pantothenic acid BP 15 mg, Folic acid BP 0.4 mg, Vitamin B12 BP 0.005 mg, Ascorbic acid BP 100 mg, Biotin BP 0.06 mg
Each 10 ml vial contains: Vitamin B1 BP 2.5 mg, Vitamin B2 BP 3.6 mg, Nicotinamide BP 40 mg, Vitamin B6 BP 4 mg, Pantothenic acid BP 15 mg, Folic acid BP 0.4 mg, Vitamin B12 BP 0.005 mg, Ascorbic acid BP 100 mg, Biotin BP 0.06 mg
Description:
Vitamin-B complex & Vitamin C IV is a lyophilized, sterile, yellow-colored porous cake or powder of water-soluble vitamins for intravenous infusion. It contains a balanced amount of all the important water-soluble vitamins. It is a sterile lyophilized mixture of Vitamin B1, Vitamin B2, Nicotinamide, Vitamin B6, Pantothenic Acid, Ascorbic Acid, Biotin, Folic Acid, and Vitamin B12.
Dosage & Administration:
Adults and children age 11 years and above: One vial (10 ml) daily.
Children below 11 years of age: Children weighing less than 10 kg should be given 1 ml of the dissolved mixture per kg body weight /day.
Children weighing 10 kg or more should be given 10 ml (one vial) of the dissolved mixture /day.
Instruction for use
The content of each vial of Vitamin-B complex & Vitamin C IV should be dissolved first and then diluted for infusion only. The content of each vial is dissolved by the aseptic addition of-
1. Water for injections
2. Glucose solution for infusion (5%-50%) or
3. Fat emulsion (10%)
Vitamin-B complex & Vitamin C IV may be added to parenteral nutrition admixtures containing carbohydrates, lipids, amino acids, and electrolytes provided that compatibility and stability have been confirmed.
Side Effects:
Allergic reactions may occur in patients hypersensitive to any component in the preparation, for example, methyl parahydroxybenzoate or thiamine. There have been rare reports of anaphylactoid reactions following repeated injection of preparations containing thiamine. Flushing, itching, or burning of the skin may occur in patients susceptible to the effects of nicotinamide. Adverse reactions that may be expected based on experience with other water-soluble vitamin compounds administered intravenously include allergic reactions, including anaphylaxis; dermatological reactions including flushing, erythema, and pruritus and CNS reactions including headache, dizziness, and agitation, etc.
Precautions:
Vitamin-B complex & Vitamin C IV must not be given undiluted. When Vitamin-B complex & Vitamin C IV is diluted with water-based solutions, the admixture should be protected from light.
Use in Pregnancy & Lactation:
Animal reproduction studies or clinical investigations during pregnancy have not been carried out with this preparation. However, there are published reports on the safe administration of water-soluble vitamins in this patient group.
Drug Interaction:
Folic acid may lower the serum concentration of phenytoin. Vitamin B6 can reduce the effect of levodopa.
Over Dose:
No adverse effects of an overdose of water-soluble vitamins have been reported, with exception of cases of extremely high parenteral doses. The possibility of hypervitaminosis A and D should be considered if the content of the Vitamin-B complex & Vitamin C IV vial is dissolved in another multivitamin injection.
Storage:
Before reconstitution: Store below 25 °C, protected from light. After reconstitution: The reconstituted Vitamin-B complex & Vitamin C IV should be added to the infusion solution aseptically immediately before the start of the infusion and used within 24 hours.
Vitamin-B complex & Vitamin C IV is a lyophilized, sterile, yellow-colored porous cake or powder of water-soluble vitamins for intravenous infusion. It contains a balanced amount of all the important water-soluble vitamins. It is a sterile lyophilized mixture of Vitamin B1, Vitamin B2, Nicotinamide, Vitamin B6, Pantothenic Acid, Ascorbic Acid, Biotin, Folic Acid, and Vitamin B12.
Dosage & Administration:
Adults and children age 11 years and above: One vial (10 ml) daily.
Children below 11 years of age: Children weighing less than 10 kg should be given 1 ml of the dissolved mixture per kg body weight /day.
Children weighing 10 kg or more should be given 10 ml (one vial) of the dissolved mixture /day.
Instruction for use
The content of each vial of Vitamin-B complex & Vitamin C IV should be dissolved first and then diluted for infusion only. The content of each vial is dissolved by the aseptic addition of-
1. Water for injections
2. Glucose solution for infusion (5%-50%) or
3. Fat emulsion (10%)
Vitamin-B complex & Vitamin C IV may be added to parenteral nutrition admixtures containing carbohydrates, lipids, amino acids, and electrolytes provided that compatibility and stability have been confirmed.
Side Effects:
Allergic reactions may occur in patients hypersensitive to any component in the preparation, for example, methyl parahydroxybenzoate or thiamine. There have been rare reports of anaphylactoid reactions following repeated injection of preparations containing thiamine. Flushing, itching, or burning of the skin may occur in patients susceptible to the effects of nicotinamide. Adverse reactions that may be expected based on experience with other water-soluble vitamin compounds administered intravenously include allergic reactions, including anaphylaxis; dermatological reactions including flushing, erythema, and pruritus and CNS reactions including headache, dizziness, and agitation, etc.
Precautions:
Vitamin-B complex & Vitamin C IV must not be given undiluted. When Vitamin-B complex & Vitamin C IV is diluted with water-based solutions, the admixture should be protected from light.
Use in Pregnancy & Lactation:
Animal reproduction studies or clinical investigations during pregnancy have not been carried out with this preparation. However, there are published reports on the safe administration of water-soluble vitamins in this patient group.
Drug Interaction:
Folic acid may lower the serum concentration of phenytoin. Vitamin B6 can reduce the effect of levodopa.
Over Dose:
No adverse effects of an overdose of water-soluble vitamins have been reported, with exception of cases of extremely high parenteral doses. The possibility of hypervitaminosis A and D should be considered if the content of the Vitamin-B complex & Vitamin C IV vial is dissolved in another multivitamin injection.
Storage:
Before reconstitution: Store below 25 °C, protected from light. After reconstitution: The reconstituted Vitamin-B complex & Vitamin C IV should be added to the infusion solution aseptically immediately before the start of the infusion and used within 24 hours.
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