Betacarotene+Vitamin C+Vitamin E: Uses,Dosage,Side Effects

Generic Names
Betacarotene + Vitamin C + Vitamin E

Therapeutic Class: Anti-oxidant Multivitamin preparations

Indications :

Antioxidant vitamins are utilized in a good range of conditions where radical damage is playing a task. Antioxidant vitamin combination is employed within the prevention of coronary heart diseases, certain sorts of cancer, aging also as radical damage caused by excessive exercise, illness, certain medications, pollution, smoke, radiation, and pesticides. the most role of the antioxidant vitamins is as follows:

β carotene prevents radical formation by quenching singlet oxygen, a highly reactive sort of oxygen. vitamin C is another radical scavenger that deactivates free radicals. It works especially within the plasma, lung fluid, aqueous humor, and extracellular fluid. It can increase white blood corpuscle activity; play important roles within the biochemistry of antibodies, prostaglandin E 1, B, and T lymphocytes, and interferon. vitamin E also scavenges free radicals within the blood alongside β carotene and vitamin C. Moreover, vitamin E is important to guard against a number of the ill effects of smog and smoke. In reference to other nutrients, vitamin E protects vitamin A from being destroyed within the body.

Pharmacology:

when required Beta carotene of this tablet is converted to vitamin A (Retinol). Retinol has several biochemical functions e.g. on retina, growth, tissue differentiation, immunological response. it's also some anti-cancer activity. Vitamin C is the most powerful reducer known to be present in living tissues. vitamin C deficiency produces scurvy. it's a cofactor in numerous biological processes. vitamin C and molecular oxygen are essential for the conversion of proline to hydroxyproline, dopamine to noradrenaline. vitamin C is additionally essential for the synthesis of adrenal steroid hormones. vitamin C is vital within the defense against infection and studies have shown that vitamin C is vital for the traditional functioning of T-lymphocyte and leukocyte. vitamin C has some anti-inflammatory activity and protects cells against the oxidation of essential molecules. In high doses, (1-2 g daily) vitamin C increases iron absorption.

vitamin E seems to be a defense against oxidative stress and lipid peroxidation. In most cell membranes there's one molecule of tocopherol for each 1000 lipid molecules. Tocopherol mops up peroxide radicals then need a supply of reduced hydrogen to revive the steady-state situation. this is often usually supplied by vitamin C or reduced glutathione.

Dosage & Administration :

This tablet is run orally. The adult dose of this mix of antioxidant vitamin tablets is 1 tablet daily or as prescribed by the physician.

Interaction:

Cholestyramine, Colestipol, Neomycin cause decreased absorption of β carotene. Circulating vitamin C levels are shown to be reduced during prolonged administration of oral contraceptives containing Oestrogen, Tetracycline, and Aspirin. The decrease in vitamin C levels could also be thanks to drug-induced impaired absorption or increased utilization of the vitamin for drug metabolism. vitamin E may enhance the anticoagulant activity of anticoagulant drugs. High doses of vitamin E can impair intestinal absorption of vitamins A and K.

Contraindications:

Carocet is contraindicated in patients with hypersensitivity to any of its components.

Side Effects:

β carotene is relatively safe even at high and prolonged exposure. Individuals who routinely ingest large amounts of carotenoids can develop hypercarotenosis, which is characterized by a yellowish coloration of the skin and a really high concentration of carotenoids within the plasma. This benign condition, although resembling jaundice, gradually disappears upon correcting the excessive intake of carotenoids.

Vitamin C is usually a secure drug for human use in normal doses. Larger doses may cause alimentary canal upset and renal stone formation. Vitamin E is taken into account safe even in large doses. Doses over 800 mg may cause diarrhea, abdominal pain or cramps, fatigue, and reduced resistance to bacterial infection, and transiently raised vital signs.

Pregnancy & Lactation:

β carotene, vitamin C, and vitamin E haven't any teratogenic effects in humans. However, like all other drug caution should be taken in prescribing to pregnant women.

Precautions & Warnings:

There is some evidence that β carotene may cause harm to heavy smokers and alcoholics. Therefore, caution should be exercised in these cases. vitamin C should tend with caution to patients with hyperoxaluria. vitamin E should be used with caution in patients taking anticoagulant drugs, because vitamin E may enhance the anticoagulant activity of those drugs.

Storage:

Should be stored during a dry place below 30˚C.